How to order

Ordering your patient’s test is easy

The Cancerguard® test can give your patients the power of early insight. This simple blood test — developed by the makers of the Cologuard® test — can help detect more cancers, even at early stages.1

4 simple steps to get your patients tested

Help your patients screen for cancer. Ordering a Cancerguard test and getting the results is simple and straightforward.

Step 1

Request blood collection kits

Woman healthcare professional smiling while on the phone at front desk

You can request blood collection kits to be shipped to you by calling our Customer Care team.

Cancerguard test supplies are provided at no charge and are to be used only with the Cancerguard test. If you don't have a kit you can also order through fax.

Call 1-844-870-8870

Step 2

Place your order

Person on a computer displaying a message that their Cancerguard test order was received

Our Provider Hub is the most efficient way to submit your order. If you don’t already have an account, it’s easy to create one.

Once your account is created, it typically takes 24-48 hours to validate your information before you can place your order

Step 3

Collect and ship samples

A nurse collecting a blood sample from a patient’s arm

The Cancerguard test will require patients to provide 4 vials of blood.

Please ship samples back to us in the supplied Cancerguard blood collection kits, according to our specimen requirements and shipping guidelines.

Step 4

Access results

An orders page displaying that the Cancerguard test result is ready

You can access your patients' results on our Provider Hub or receive the report by fax.

Most Cancerguard test reports are available within two weeks.

Support after a positive result

Exact Sciences provides Care Navigation education and resources to streamline next steps after a positive Cancerguard test result, including:2

Post-positive care education and resources from our team of dedicated care navigators
Ready-to-use workflows to help care team manage next steps
Education from Exact Sciences MSLs and Lab Medical Directors
Access to our Imaging-Based Diagnostic Resolution Guidebook
Health care provider reviewing information with a patient in a clinic waiting room.
A close up of the orders and results webpage.
Exact Sciences Provider Hub

Access everything all in one place

With Exact Sciences' online Provider Hub, ordering a test, tracking test progress, and accessing results is convenient and efficient.

  • Orders can be submitted online — virtually eliminating the need for follow-up calls to complete any missing information.
  • All patient orders and results can be viewed, tracked, and sorted quickly.
  • Orders and results may be viewed online, printed, or downloaded as PDFs.

Get started now, even if you're new to Exact Sciences

The Provider Hub is the easiest way to order the Cancerguard test. But, if you’re new to Exact Sciences, you don’t have to wait for your account to be verified. You can start placing orders immediately with a paper Test Requisition Form (TRF). Here's how:

  • Download the Test Requisition Form (TRF)
  • Select “Exact Managed” as the sample collection method
  • Fax or email the completed TRF to Exact Sciences
  • Kits are shipped directly to your patient, who will receive a notification to self-schedule their blood draw

Test Requisition Form

Please download a copy of the form, complete it, and fax it to 1-608-709-0769.

Blood collection kits

Give us a call to get blood collection kits sent to your office. Or you can contact your local Exact Sciences sales representative.
Call +844-870-8870

Have questions?

Call us at 844-870-8870

Important Information about the Cancerguard Test


Rx only. The Cancerguard® test is indicated for use in adults ages 50-84 with no known cancer diagnosis in the last three years. It detects alterations in circulating tumor DNA and tumor-associated protein levels which are commonly associated with cancer. The test does not detect all cancers and is not a replacement for existing recommended cancer screening or diagnostic modalities for cancer. Current recommended screening for cancer should also be followed. The test is not indicated for screening of breast and prostate cancer and was not evaluated for the detection of pre-cancerous lesions. Due to the potential for follow-up imaging with IV contrast CT after a positive test result, careful consideration should be given before ordering the Cancerguard test for patients with a history of adverse reactions to iodine based IV contrast or for women who are, may be, or plan to become pregnant. Results should be interpreted in the context of a patient’s medical history, clinical signs, and symptoms. A negative result does not rule out the presence of cancer of any type. A positive Cancerguard® test result means that the blood test identified a cancer signal that may indicate the presence of cancer. This result alone does not confirm the presence of cancer. Further clinical evaluation by a healthcare provider (which may include blood tests such as complete blood count and comprehensive metabolic panel) and follow-up imaging are needed to locate and confirm a diagnosis of cancer or determine that cancer is not present. While there are no established guidelines for imaging following a positive Cancerguard test result, there is a published follow-up workflow based on expert clinician opinion and results from an exploratory, prospective, interventional study [Kisiel et al Life (Basel) 2024 Jul 24; Lennon et al, Science, 2020]. The proposed workflow in the Kisiel et al publication includes an intravenous-contrast enhanced computed tomography (IV contrast CT of chest, abdomen/pelvis, and soft-tissue neck) and if necessary, positron emission tomography-computed tomography (18F FDG PET-CT) from the skull-base to mid-thigh. Alternative follow-up procedures (e.g. targeted imaging, endoscopic procedures, CT without IV- contrast) may be appropriate in the context of the patient’s medical history and clinical evaluation [Lennon et al, Science, 2020]. False positive and false negative test results can occur.

The Cancerguard test was developed, and the performance characteristics validated by Exact Sciences Laboratories following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. This test has not been cleared or approved by the US Food and Drug Administration. The test is performed at Exact Sciences Laboratories. Exact Sciences Laboratories is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing.